ヨウ素から不斉合成触媒を開発=次世代抗生物質の生成に期待-名古屋大
2月18日0時20分配信 時事通信
右手と左手のように鏡面対称の構造を持つ二つの分子のうち、一方だけを合成する「不斉(ふせい)合成」を、名古屋大の石原一彰教授らの研究グループがヨ
ウ素を用いた触媒で成功させた。合成された物質からは、次世代の抗生物質などを生成できる可能性があるという。研究成果は17日までに、独化学誌アンゲバ
ンテ・ケミー電子版に掲載された。
物質の中には合成すると同じ分子式なのに、構造が鏡面対称になる2種類ができるものがある。二つは性質が異なるため、医薬品などを作る際は有用な性質を持つ片方だけを不斉合成する必要がある。
石原教授らは、ヨウ素を用いた有機化合物を触媒とし、アルコールの一種である分子を酸化させ、医薬品中間体「スピロラクトン」を不斉合成した。
スピロラクトンからは「ラクトナマイシン」という次世代抗生物質や抗がん剤を生成できる可能性があるという。
Bromine-Catalyzed Aerobic Oxidation of Alcohols |
Muhammet Uyanik, Dr. 1, Ryota Fukatsu 1, Kazuaki Ishihara, Prof. Dr. 1 2 * |
1Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603 (Japan), Fax: (+81) 52-789-3222 2Japan Science and Technology (JST), CREST, Furo-cho, Chikusa-ku, Nagoya, 464-8603 (Japan) |
email: Kazuaki Ishihara (ishihara@cc.nagoya-u.ac.jp) |
*Correspondence to Kazuaki Ishihara, 1Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603 (Japan), Fax: (+81) 52-789-3222
Funded by:
JSPS.KAKENHI; Grant Number: 20245022
New Energy and Industrial Technology Development Organization (NEDO)
MEXT
Keywords |
acid • aerobic • alcohol • bromine • oxidation |
Abstract |
Simple and clean: We have demonstrated that a simple and environmentally benign catalytic system HBr/NaNO2 is very effective for the selective oxidation of alcohols under balloon pressure of O2. Furthermore, the aerobic oxidation of alcohols has been achieved under balloon pressure of air rather that pure O2, with this HBr/NaNO2/HNO3 catalytic system. |
Received: 1 November 2009
Digital Object Identifier (DOI) |
10.1002/asia.200900609 About DOI
x^(`σ∞ ´э)э・・・・・・・・
臭化水素なら記載されているが、ヨウ素は無いようだが・・・・
どういうことだ?と思う午後。
옥소로부터 고르지 않음 합성 촉매를 개발=차세대 항생 물질의 생성에 기대-나고야대
2월 18일 0시 20 분배신 시사 통신
물질안에는 합성하는과 같은 분자식인데, 구조가 경면 대칭이 되는 2 종류가 생기는 것이 있다.둘은 성질이 다르기 위해, 의약품등을 만들 때는 유용한 성질을 가지는 다른 한쪽만을 고르지 않음 합성할 필요가 있다.
이시하라 교수들은, 옥소를 이용한 유기 화합물을 촉매로 해, 알코올의 일종인 분자를 산화시켜, 의약품 중간체「스피로 락톤」를 고르지 않음 합성했다.
스피로 락톤에서는「라크트나마이신」라고 하는 차세대 항생 물질이나 항암제를 생성할 수 있을 가능성이 있다고 한다.
Communication
Bromine-Catalyzed Aerobic Oxidation of Alcohols |
Muhammet Uyanik, Dr. 1, Ryota Fukatsu 1, Kazuaki Ishihara, Prof. Dr. 1 2 * |
1Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603 (Japan), Fax: (+81) 52-789-3222 2Japan Science and Technology (JST), CREST, Furo-cho, Chikusa-ku, Nagoya, 464-8603 (Japan) |
email: Kazuaki Ishihara (ishihara@cc.nagoya-u.ac.jp) |
*Correspondence to Kazuaki Ishihara, 1Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603 (Japan), Fax: (+81) 52-789-3222
Funded by:
JSPS.KAKENHI; Grant Number: 20245022
New Energy and Industrial Technology Development Organization (NEDO)
MEXT
Keywords |
acid • aerobic • alcohol • bromine • oxidation |
Abstract |
Simple and clean: We have demonstrated that a simple and environmentally benign catalytic system HBr/NaNO2 is very effective for the selective oxidation of alcohols under balloon pressure of O2. Furthermore, the aerobic oxidation of alcohols has been achieved under balloon pressure of air rather that pure O2, with this HBr/NaNO2/HNO3 catalytic system. |
Received: 1 November 2009
Digital Object Identifier (DOI) |
10.1002/asia.200900609 About DOI
x^(`σ∞ ´э) э・・・・・・・・
취화수소라면 기재되어 있지만, 옥소는 없는 것 같지만 ・・・・
무슨 일이야?(이)라고 생각하는 오후.